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Sophia Randolph Selected Research

nirogacestat

1/2014Intermittent oral coadministration of a gamma secretase inhibitor with dexamethasone mitigates intestinal goblet cell hyperplasia in rats.
7/2012Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.
6/2010Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.

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Sophia Randolph Research Topics

Disease

6Neoplasms (Cancer)
01/2020 - 06/2010
4Fatigue
01/2020 - 01/2015
4Breast Neoplasms (Breast Cancer)
11/2016 - 01/2015
3Neutropenia
11/2016 - 01/2015
2Anemia
11/2016 - 07/2015
2Leukopenia
11/2016 - 07/2015
2Disease Progression
11/2016 - 07/2015
2Febrile Neutropenia
11/2016 - 07/2015
2Multiple Myeloma
01/2015 - 08/2012
2Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
07/2012 - 06/2010
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
07/2012 - 06/2010
1Thrombocytopenia (Thrombopenia)
07/2015
1Back Pain (Backache)
01/2015
1Pulmonary Embolism
01/2015
1Melanoma (Melanoma, Malignant)
07/2014
1Hyperplasia
01/2014
1Metaplasia
07/2012
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
05/2012
1Ovarian Neoplasms (Ovarian Cancer)
03/2011
1Retinoblastoma (Glioblastoma, Retinal)
03/2011
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
05/2008
1Mycosis Fungoides
05/2008
1Lymphoma (Lymphomas)
05/2008
1Leukemia
09/2003
1Graft vs Host Disease (Graft-Versus-Host Disease)
09/2003

Drug/Important Bio-Agent (IBA)

8palbociclibIBA
11/2016 - 03/2011
4Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2016 - 01/2015
3Letrozole (Femara)FDA LinkGeneric
11/2016 - 01/2015
3Dexamethasone (Maxidex)FDA LinkGeneric
01/2015 - 07/2012
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2014 - 06/2010
3nirogacestatIBA
01/2014 - 06/2010
2Estrogen ReceptorsIBA
11/2016 - 01/2016
2human ERBB2 proteinIBA
11/2016 - 01/2016
2Cyclin-Dependent Kinase 4IBA
01/2015 - 08/2012
2Bortezomib (Velcade)FDA Link
01/2015 - 08/2012
2Retinoblastoma ProteinIBA
07/2014 - 05/2012
1CrizotinibIBA
01/2020
1Alanine Transaminase (SGPT)IBA
01/2020
1ErbB Receptors (EGF Receptor)IBA
07/2015
1Hormones (Hormone)IBA
07/2015
1Fulvestrant (Faslodex)FDA Link
07/2015
1Cyclin-Dependent Kinase Inhibitor p16IBA
01/2015
1Cyclin D1IBA
01/2015
1Biomarkers (Surrogate Marker)IBA
01/2015
1Proteins (Proteins, Gene)FDA Link
07/2014
1GlucocorticoidsIBA
07/2012
1Glucose (Dextrose)FDA LinkGeneric
05/2012
1Phosphotransferases (Kinase)IBA
03/2011
1Notch ReceptorsIBA
06/2010
1VorinostatFDA Link
05/2008
1Histone Deacetylase InhibitorsIBA
05/2008
1Minor Histocompatibility AntigensIBA
09/2003

Therapy/Procedure

3Therapeutics
07/2015 - 06/2010
1Oral Administration
01/2014
1Hematopoietic Stem Cell Transplantation
09/2003